Study Description Modal 2

Study Description

Based on an analysis of data from the Hopkins Lupus Cohort study of 2,265 patients over 26 years, investigating impact of [glucocorticoid] doses on risk of organ damage development. At the time of this analysis, the cohort included 2,265 patients with SLE who were followed over the course of 26 years between 1987 and October 2012, with the average duration of follow-up from cohort entry until lost to follow-up being 6.2 years. Cox proportional hazards models were used to estimate the impact of different levels of exposure to [glucocorticoids] (as defined by [glucocorticoid] cut-off points endorsed in some SLE clinical trials) on the risk of developing any new organ damage or any new organ damage at the individual organ systems over time. Organ damage was measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) or by components of the SDI at the individual organ systems level.34